Call: Systems approaches for the discovery of combinatorial therapies for complex disorders

Programme	Horizon 2020 - Societal Challenges
Type of Fund	Action programme
Description of programme "Horizon 2020 - Societal Challenges "	A challenge-based approach will bring together resources and knowledge across different fields, technologies and disciplines, including social sciences and the humanities. This will cover activities from research to market with a new focus on innovation-related activities, such as piloting, demonstration, test-beds, and support for public procurement and market uptake. Funding focuses on the following challenges: Health, demographic change and wellbeing; Food security, sustainable agriculture and forestry, marine and maritime and inland water research, and the Bioeconomy; Secure, clean and efficient energy; Smart, green and integrated transport; Climate action, environment, resource efficiency and raw materials; Europe in a changing world - inclusive, innovative and reflective societies; Secure societies - protecting freedom and security of Europe and its citizens.
Link	Link to Programme
Description of programme "Health, Demographic Change and Wellbeing"	Responding to the challenge of an aging population, research and innovation (R&I) under Horizon 2020 is an investment in better health for all. It aims to keep older people active and independent for longer and supports the development of new, safer and more effective interventions. R&I under Horizon 2020 also contributes to the sustainability of health and care systems.
Call	Systems approaches for the discovery of combinatorial therapies for complex disorders
Description of call "Systems approaches for the discovery of combinatorial therapies for complex disorders"	Many complex disorders pose a challenge to identify the most effective therapeutic interventions because current therapies often target specific aspects of a disease, without achieving complete control or the best possible results for patients. Due to the multiple causes of such diseases and the heterogeneity between patients, approaches directed at single targets have had limited efficacy, overlooking important factors involved in disease pathophysiology. Hence, a promising therapeutic approach to meet this challenge is to combine different therapies, while increasing therapeutic efficacy in a cost-effective manner. Research should aim to understand at systems level the pathophysiology of a disorder in groups of patients responding well or poorly to particular therapies and further develop combinatorial therapies tailored to the needs of individuals or stratified patient groups.
Link	Link to Call
Thematic Focus	Innovation, Research, Health
Funding area	EU Member States Albania / Shqipëria Bosnia and Herzegovina Iceland / Ísland Moldova Montenegro / Crna Gora/Црна Гора North Macedonia / Северна Македонија Norway / Norge Serbia / Сpбија Switzerland / Schweiz / Suisse / Svizzera Turkey / Türkiye Ukraine / Україна Oukraïna Others
Origin of Applicant	EU Member States Albania / Shqipëria Bosnia and Herzegovina Iceland / Ísland Moldova Montenegro / Crna Gora/Црна Гора North Macedonia / Северна Македонија Norway / Norge Serbia / Сpбија Switzerland / Schweiz / Suisse / Svizzera Turkey / Türkiye Ukraine / Україна Oukraïna Others
Eligible applicants	Education and Training Centres, Federal State / Region / City / Municipality / Local Authority, Research Institution, Lobby Group / Professional Association / Trade Union, International Organization, Small and Medium Sized Enterprises, SMEs (between 10 and 249 employees), Microenterprises (fewer than 10 employees), NGO / NPO, University, Enterprise (more than 250 employees or not defined), Association
Applicant details	All legal entities located in the EU or in Third Countries can participate in Horizon 2020.
Project Partner	Yes
Project Partner Details	As a principle all projects (except coordination and support activities) must comprise at least 3 partners from at least 3 EU Member States or other eligible countries.
Further info	This call follows a two-stage submission procedure. For the first stage, a short proposal of max. 10 pages needs to be submitted. Maximum 3 months after the submission, the applicants selected will be notified and invited to submit their full proposal until 16.04.2019.
Type of Funding	Grants
Financial details	Total call-budget: 50 million € Indicative budget per project: 3-4 million € Co-financing rate: max. 100%
Submission	Online via Participant Portal
Contact Details	Link to the National Contact Point Finder.