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Call key data
Improving the quality of life of persons with intellectual disabilities and their families
Funding Program
Horizon Europe: Cluster 1 - Health
Call number
HORIZON-HLTH-2025-03-STAYHLTH-01-two-stage
deadlines
Opening
22.05.2025
Deadline
16.09.2025 17:00
Funding rate
100%
Call budget
€ 40,000,000.00
Estimated EU contribution per project
between € 6,000,000.00 and € 8,000,000.00
Link to the call
Link to the submission
Call content
short description
This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Staying healthy in a rapidly changing society”.
Call objectives
The scope of this topic is set by the definitions provided by ‘The international classification of diseases’ - World Health Organization (WHO) ICD11 under ‘6A00: Disorders of intellectual development’ and under ‘20: Developmental anomalies’ including disorders of intellectual development, such as ‘LD40: Complete trisomies of the autosomes’ and ‘LD90: Conditions with disorders of intellectual development as a relevant clinical feature’. Moreover, the three types of autism with disorders of intellectual development (6A02.1, 6A02.3 and 6A02.5) under ‘6A02: Autism spectrum disorder’ are also within the scope of this topic.
The focus of this topic is human-centred on the persons with long-term intellectual disabilities and their formal and informal carers, including families. The life expectancy of persons with intellectual disabilities has increased in the last 20 years, which makes it even more important to analyse the role of their families acting as informal carers (e.g. ageing parents).
The objective of this topic is to explore new ways to improve the quality of life of persons with intellectual disabilities and their families and to reduce to the maximum possible the negative impact of the disability in their daily lives from different perspectives, such as medical, technological, digital or others. A key element to improve their quality of life is to prevent the worsening of the disability or conditions originating it. Thus, research needs to look from different perspectives into finding the causes of the disease(s) originating the disability and/or reducing as much as possible its level of severity.
Innovative solutions are needed to provide novel medicines, diagnoses, treatments, protocols, technologies or digital solutions, etc. that can help in an early stage to prevent the worsening of the intellectual disability and/or related co-morbidities, reverse or reduce it, and to improve the autonomy of affected persons and relieve their carers.
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Expected effects and impacts
Research actions under this topic should address several of the following areas:
- To properly diagnose as early as possible the disease(s) causing the intellectual disability or conditions worsening them, especially in the case of children, and paying attention to sex and gender-related differences and diagnostic biases.
- Deliver the necessary medical treatments, diagnoses, medicines, protocols, technologies, digital solutions, habilitation and/or rehabilitation services, etc. that can help preventing the worsening of the intellectual disability, reversing it or reducing its severity, while supporting the empowerment of the person with intellectual disabilities. Any health technology or medical intervention developed for human use must comply with the relevant regulatory requirements and be based on sound scientific evidence to ensure safety and efficacy.
- Tackle comorbidities or other disabilities that persons with intellectual disabilities may suffer from, with awareness of sex and gender-related differences.
- Provide evidence-based approaches for transitional care for young adults with intellectual disabilities, addressing also sex and gender-specific challenges and needs, the transition from paediatric to adult care being perceived as complex to navigate.
- Promote the empowerment among persons with intellectual disabilities and their caregivers, and whenever possible remove barriers persons with intellectual disabilities face for their participation in society. If applicable, with the support of assistive technologies and digital solutions, ensure optimal autonomy of persons with intellectual disabilities, facilitate and improve the treatment of persons with intellectual disabilities, and help also the family members and close carers to better support persons with intellectual disabilities. Such technologies must adhere to the relevant standards and be grounded in scientific evidence.
- Propose innovative solutions for high quality, accessible - including cognitively accessible - and affordable care services, to allow carers of persons with intellectual disabilities to better balance their work and family lives. The role of informal/unpaid carers, especially family members, is of key importance for persons with intellectual disabilities. For many persons with intellectual disabilities, the lack of care services and insufficient support for families and personal assistance undermines their quality of life and their rights and possibility to live as independently as possible.
- Develop innovative integrated care strategies - strengthening patient-centred care - to improve the Quality of Life of persons with intellectual disabilities of any age, and their families, paying special attention to persons with intellectual disabilities with the highest vulnerability because of their high dependency on carers (formal and/or informal), multiple disabilities and need of adapted and special care (medical, social, educational and psychological dimensions).
- Develop guidelines in order to provide adequate support and training for caregivers, formal and informal, especially for those providing care for persons with intellectual disabilities and/or living with them, and also addressing the issue of prevention of and protection from violence since persons with intellectual disabilities are both vulnerable to violence and abuse and can be violent towards care givers and family members.
Applicants are encouraged to include patients, their families and carers in the different stages of the research. Likewise, it is encouraged to involve stakeholders from within and outside the intellectual disabilities sector, in particular policymakers and public authorities, citizens and civil society organisations, end-users and service providers.
This topic requires the effective contribution of social sciences and humanities (SSH) disciplines and the involvement of SSH experts, institutions as well as the inclusion of relevant SSH expertise, in order to produce meaningful and significant effects enhancing the societal impact of the related research activities.
All projects funded under this topic are encouraged to participate in networking and joint activities, as appropriate. These networking and joint activities could, for example, involve the participation in joint workshops, the exchange of knowledge, the development and adoption of best practices, or joint communication activities. Therefore, proposals are expected to include a budget for the attendance to regular joint meetings and may consider covering the costs of any other potential joint activities without the prerequisite to detail concrete joint activities at this stage. The details of these joint activities will be defined during the grant agreement preparation phase.
Projects are also encouraged to explore potential complementarities with projects funded under the Cluster 2 topic HORIZON-CL2-2025-01-TRANSFO-09: “Good practices for increased autonomy of persons with disabilities, including physical, mental, intellectual and sensory disabilities” are encouraged.
Applicants invited to the second stage and envisaging to include clinical studies should provide details of their clinical studies in the dedicated annex using the template provided in the submission system.
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Expected results
To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to several of the following expected outcomes:
- Persons with intellectual disabilities and their families enjoy an improved quality of life, are empowered and have more independence through the support of innovative research.
- The scientific community develops innovative solutions - medical, technological, digital or others - to reverse and/or reduce the severity level of the intellectual disability as soon as possible, especially in children, improving the health and autonomy of persons with intellectual disabilities and relieving their carers.
- Policymakers, health and care services, patient organisations, funders, the scientific community, and other relevant bodies are informed of the research advances and best practices addressing the health and needs of persons with intellectual disabilities and help reduce the impact of those disabilities on individuals, their families and society.
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Eligibility Criteria
Regions / countries for funding
Moldova (Moldova), Albania (Shqipëria), Armenia (Հայաստան), Bosnia and Herzegovina (Bosna i Hercegovina / Босна и Херцеговина), Canada, Faeroes (Føroyar / Færøerne), Georgia (საქართველო), Iceland (Ísland), Israel (ישראל / إِسْرَائِيل), Kosovo (Kosova/Kosovë / Косово), Montenegro (Црна Гора), New Zealand (Aotearoa), North Macedonia (Северна Македонија), Norway (Norge), Serbia (Srbija/Сpбија), Tunisia (تونس /Tūnis), Türkiye, Ukraine (Україна), United Kingdom
eligible entities
EU Body, Education and training institution, Non-Profit Organisation (NPO) / Non-Governmental Organisation (NGO), Other, Private institution, incl. private company (private for profit), Public Body (national, regional and local; incl. EGTCs), Research Institution incl. University, Small and medium-sized enterprise (SME)
Mandatory partnership
Yes
Project Partnership
To be eligible for funding, applicants must be established in one of the following countries:
- the Member States of the European Union, including their outermost regions
- the Overseas Countries and Territories (OCTs) linked to the Member States
- countries associated to Horizon Europe - see list of particpating countries
Only legal entities forming a consortium are eligible to participate in actions provided that the consortium includes, as beneficiaries, three legal entities independent from each other and each established in a different country as follows:
- at least one independent legal entity established in a Member State; and
- at least two other independent legal entities, each established in different Member States or Associated Countries.
In recognition of the opening of the US National Institutes of Health’s programmes to European researchers, any legal entity established in the United States of America is eligible to receive Union funding.
Any legal entity, regardless of its place of establishment, including legal entities from non-associated third countries or international organisations (including international European research organisations) is eligible to participate (whether it is eligible for funding or not), provided that the conditions laid down in the Horizon Europe Regulation have been met, along with any other conditions laid down in the specific call topic.
A ‘legal entity’ means any natural or legal person created and recognised as such under national law, EU law or international law, which has legal personality and which may, acting in its own name, exercise rights and be subject to obligations, or an entity without legal personality.
other eligibility criteria
Specific cases:
- Affiliated entities (i.e. entities with a legal or capital link to a beneficiary which participate in the action with similar rights and obligations to the beneficiaries, but which do not sign the grant agreement and therefore do not become beneficiaries themselves) are allowed, if they are eligible for participation and funding.
- Associated partners (i.e. entities which participate in the action without signing the grant agreement, and without the right to charge costs or claim contributions) are allowed, subject to any conditions regarding associated partners set out in the specific call conditions.
- Entities which do not have legal personality under their national law may exceptionally participate, provided that their representatives have the capacity to undertake legal obligations on their behalf, and offer guarantees to protect the EU’s financial interests equivalent to those offered by legal persons.
- Legal entities created under EU law (EU bodies) including decentralised agencies may be part of the consortium, unless provided for otherwise in their basic act.
- International European research organisations are eligible to receive funding. International organisations with headquarters in a Member State or Associated Country are eligible to receive funding for ‘Training and mobility’ actions or when provided for in the specific call/topic conditions. Other international organisations are not eligible to receive funding, unless provided for in the specific call/topic conditions, or if their participation is considered essential for implementing the action by the granting authority.
- Joint Research Centre (JRC)— Where provided for in the specific call conditions, applicants may include in their proposals the possible contribution of the JRC but the JRC will not participate in the preparation and submission of the proposal. Applicants will indicate the contribution that the JRC could bring to the project based on the scope of the topic text. After the evaluation process, the JRC and the consortium selected for funding may come to an agreement on the specific terms of the participation of the JRC. If an agreement is found, the JRC may accede to the grant agreement as beneficiary requesting zero funding or participate as an associated partner, and would accede to the consortium as a member.
- Associations and interest groupings — Entities composed of members (e.g. European research infrastructure consortia (ERICs)) may participate as ‘sole beneficiaries’ or ‘beneficiaries without legal personality’. However, if the action is in practice implemented by the individual members, those members should also participate (either as beneficiaries or as affiliated entities, otherwise their costs will NOT be eligible.
- EU restrictive measures — Entities subject to EU restrictive measures under Article 29 of the Treaty on the European Union (TEU) and Article 215 of the Treaty on the Functioning of the EU (TFEU) as well as Article 75 TFEU, are not eligible to participate in any capacity, including as beneficiaries, affiliated entities, associated partners, third parties giving in-kind contributions, subcontractors or recipients of financial support to third parties (if any).
- Legal entities established in Russia, Belarus, or in non-government controlled territories of Ukraine — Given the illegal invasion of Ukraine by Russia and the involvement of Belarus, there is currently no appropriate context allowing the implementation of the actions foreseen in this programme with legal entities established in Russia, Belarus, or in non-government controlled territories of Ukraine. Therefore, even where such entities are not subject to EU restrictive measures, such legal entities are not eligible to participate in any capacity. This includes participation as beneficiaries, affiliated entities, associated partners, third parties giving in-kind contributions, subcontractors or recipients of financial support to third parties (if any). Exceptions may be granted on a case-by-case basis for justified reasons.
With specific regard to measures addressed to Russia, following the adoption of the Council Regulation (EU) 2024/1745 of 24 June 2024 (amending Council Regulation (EU) No 833/2014 of 31 July 2014) concerning restrictive measures in view of Russia’s actions destabilising the situation in Ukraine, legal entities established outside Russia but whose proprietary rights are directly or indirectly owned for more than 50% by a legal person, entity or body established in Russia are also not eligible to participate in any capacity. - Measures for the protection of the Union budget against breaches of the principles of the rule of law in Hungary — Following the Council Implementing Decision (EU) 2022/2506, as of 16 December 2022, no legal commitments can be entered into with Hungarian public interest trusts established under the Hungarian Act IX of 2021 or any entity they maintain. Affected entities may continue to apply to calls for proposals and can participate without receiving EU funding, as associated partners, if allowed by the call conditions. However, as long as the Council measures are not lifted, such entities are not eligible to participate in any funded role (beneficiaries, affiliated entities, subcontractors, recipients of financial support to third parties, etc.).In case of multi-beneficiary grant calls, applicants will be invited to remove or replace that entity in any funded role and/or to change its status into associated partner. Tasks and budget may be redistributed accordingly.
Additional information
Topics
Relevance for EU Macro-Region
EUSAIR - EU Strategy for the Adriatic and Ionian Region, EUSALP - EU Strategy for the Alpine Space, EUSBSR - EU Strategy for the Baltic Sea Region, EUSDR - EU Strategy for the Danube Region
UN Sustainable Development Goals (UN-SDGs)
Additional Information
Applications must be submitted electronically via the Funders & Tenders Portal electronic submission system (accessible via the topic page in the Search Funding & Tenders section). Paper submissions are NOT possible.
Applications must be submitted using the forms provided inside the electronic submission system (not the templates available on the topic page, which are only for information). The structure and presentation must correspond to the instructions given in the forms.
Applications must be complete and contain all parts and mandatory annexes and supporting documents.
The application form will have two parts:
- Part A (to be filled in directly online) contains administrative information about the applicant organisations (future coordinator and beneficiaries and affiliated entities), the summarised budget for the proposal and call-specific questions;
- Part B (to be downloaded from the Portal submission system, completed and then assembled and re-uploaded as a PDF in the system) contains the technical description of the project.
Annexes and supporting documents will be directly available in the submission system and must be uploaded as PDF files (or other formats allowed by the system).
The page limit for the Part B for the first stage of the 2-stage call is 10 pages.
This topic is part of the blind evaluation pilot under which first stage proposals will be evaluated blindly. Applicants submitting a proposal under the blind evaluation pilot must not disclose their organisation names, acronyms, logos nor names of personnel in the proposal abstract and Part B of their first-stage application.
Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021 authorising the use of lump sum contributions under the Horizon Europe Programme – the Framework Programme for Research and Innovation (2021-2027) – and in actions under the Research and Training Programme of the European Atomic Energy Community (2021-2025). It is mandatory to submit a detailed budget table using the template available in the Submission system.
Call documents
Horizon Europe Work Programme 2025 Cluster 1 - HealthHorizon Europe Work Programme 2025 Cluster 1 - Health(1200kB)
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