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Call key data
Understanding the effects of environmental exposure on the risk of paediatric, adolescent and young adult cancers
Funding Program
Horizon Europe: Missions
Call number
HORIZON-MISS-2025-02-CANCER-02
deadlines
Opening
06.05.2025
Deadline
16.09.2025 17:00
Funding rate
100%
Call budget
€ 30,451,664.00
Estimated EU contribution per project
between € 6,000,000.00 and € 7,000,000.00
Link to the call
Link to the submission
Call content
short description
This topic contributes to the Cancer Mission objectives by improving the understanding of the impact of environmental exposures including, their interaction with other relevant factors on cancer onset and progression and/or other relevant health outcomes along the cancer patient journey. The age group of interest for this topic includes children, adolescents and young adults (less than 40 years of age at first cancer diagnosis).
Call objectives
Applicants should take advantage of technological advances which have opened up new opportunities to collect, combine and analyse large datasets of diverse types, offering new possibilities to design epidemiological studies to understand the mechanistic contribution of environmental factors, in combination with other individual and contextual factors as appropriate. Innovative and data intensive approaches are expected for the identification of time windows of susceptibility and of robust biomarkers of cumulative environmental exposure.
Proposals may envisage the creation of large cohort(s) by pooling and integrating existing retrospective studies in the areas of clinical research, exposome research, cancer registries and complementing with the new collection of other relevant data where needed (other omics data, digital pathology, behavioural and socio-economic data, clinical records etc.). Sex and gender differences should be duly considered. The use of causal interference, computational modelling and/or artificial intelligence tools are encouraged for the analysis and management of big, complex and heterogeneous data sets. All datasets produced should be described with metadata records in the EU dataset catalogue of the future European Health Data Space while all tools and models should follow the principles of open science and be made available through the future UNCAN.eu platform.
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Expected effects and impacts
The applicants should address several of the following activities:
- Identify, validate and document different types (and/or combinations) of biomarkers for the development of robust quantitative measures of the effects of cumulative environmental exposures associated with cancer onset;
- Elaborate and test cost effective approaches for measuring biomarkers of cumulative environmental exposure in large paediatric, adolescent and young adult populations, also by applying new analytical tools and novel methods of analysis;
- Identify individual signatures (e.g. based on genetic, epigenetic, multi-omic characteristics), and time windows conferring susceptibility to environmental hazards associated with cancer onset and progression in children, adolescent and young adults at different stages of the life course;
- Identify clinical states, lifestyle and socio-economic factors and circumstances that increase the risk of adverse health outcomes associated with exposure to environmental hazards in different time windows in young cancer patients;
- Develop new tools and methods to combine and analyse multimodal data, including the application of novel data-intensive methods of analysis, while ensuring interoperability with the future UNCAN.eu research platform and taking advantage of current European research infrastructures.
Advantage should be taken to the extent possible of data and experience gained under current large-scale initiatives such as: the European Human Exposome Network (EHEN), the European Partnership for the Assessment of Risks from Chemicals (PARC), the clusters of projects under the environment, climate and health research portfolio and the projects under the 'Understanding' project cluster of the Cancer Mission. The relevant EU research and health infrastructures should be exploited for available digital tools and services for dataset creation, standardisation, data discovery, secure access, management, visualization, harmonization, analysis and other functions as appropriate. Successful proposals are expected to establish appropriate collaborations with HORIZON-MISS-2024-CANCER-01-01 'Use cases for the UNCAN.eu research data platform'.
The Commission will facilitate coordination with other EU initiatives. Proposals should include a budget for networking, attendance at meetings and joint activities of the 'Understanding' project cluster of the Cancer Mission.
Proposals should consider the involvement of the European Commission's JRC regarding its experience in this field and with respect to the value it could bring in providing an effective interface between research activities and pre-normative science as well as strategies and frameworks that address regulatory requirements. In that respect, the JRC will consider collaborating with any successful proposal and this collaboration, when relevant, should be established after the proposal’s approval.
Applicants envisaging to include clinical studies should provide details in the dedicated annex using the template provided in the submission system.
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Expected results
Project results are expected to contribute to some of the following expected outcomes:
- Researchers and health professionals will advance our understanding on how environmental, genetic and epigenetic, omics and other factors interact in determining the onset and development of cancers in children, adolescents and young adults and how they impact health outcomes in young cancer patients.
- Policymakers and public health authorities have scientific evidence to improve prevention strategies to minimise the impacts of environmental factors on the development and progression of paediatric, adolescent and young adult cancers.
- Researchers, innovators, and professionals from across different disciplines and sectors will support and contribute to the future UNCAN.eu research data platform by ensuring interoperability of data, new digital tools and models.
Eligibility Criteria
Regions / countries for funding
Moldova (Moldova), Albania (Shqipëria), Armenia (Հայաստան), Azerbaijan (Azərbaycan), Bosnia and Herzegovina (Bosna i Hercegovina / Босна и Херцеговина), Canada, Faeroes (Føroyar / Færøerne), Georgia (საქართველო), Iceland (Ísland), Israel (ישראל / إِسْرَائِيل), Kosovo (Kosova/Kosovë / Косово), Montenegro (Црна Гора), Morocco (المغرب), New Zealand (Aotearoa), North Macedonia (Северна Македонија), Norway (Norge), Serbia (Srbija/Сpбија), Tunisia (تونس /Tūnis), Türkiye, Ukraine (Україна), United Kingdom
eligible entities
EU Body, Education and training institution, Non-Profit Organisation (NPO) / Non-Governmental Organisation (NGO), Other, Private institution, incl. private company (private for profit), Public Body (national, regional and local; incl. EGTCs), Research Institution incl. University, Small and medium-sized enterprise (SME)
Mandatory partnership
Yes
Project Partnership
To be eligible for funding, applicants must be established in one of the following countries:
- the Member States of the European Union, including their outermost regions
- the Overseas Countries and Territories (OCTs) linked to the Member States
- countries associated to Horizon Europe - see list of particpating countries
Only legal entities forming a consortium are eligible to participate in actions provided that the consortium includes, as beneficiaries, three legal entities independent from each other and each established in a different country as follows:
- at least one independent legal entity established in a Member State; and
- at least two other independent legal entities, each established in different Member States or Associated Countries.
Any legal entity, regardless of its place of establishment, including legal entities from non-associated third countries or international organisations (including international European research organisations) is eligible to participate (whether it is eligible for funding or not), provided that the conditions laid down in the Horizon Europe Regulation have been met, along with any other conditions laid down in the specific call topic.
A ‘legal entity’ means any natural or legal person created and recognised as such under national law, EU law or international law, which has legal personality and which may, acting in its own name, exercise rights and be subject to obligations, or an entity without legal personality.
other eligibility criteria
Specific cases:
- Affiliated entities (i.e. entities with a legal or capital link to a beneficiary which participate in the action with similar rights and obligations to the beneficiaries, but which do not sign the grant agreement and therefore do not become beneficiaries themselves) are allowed, if they are eligible for participation and funding.
- Associated partners (i.e. entities which participate in the action without signing the grant agreement, and without the right to charge costs or claim contributions) are allowed, subject to any conditions regarding associated partners set out in the specific call conditions.
- Entities which do not have legal personality under their national law may exceptionally participate, provided that their representatives have the capacity to undertake legal obligations on their behalf, and offer guarantees to protect the EU’s financial interests equivalent to those offered by legal persons.
- Legal entities created under EU law (EU bodies) including decentralised agencies may be part of the consortium, unless provided for otherwise in their basic act.
- International European research organisations are eligible to receive funding. International organisations with headquarters in a Member State or Associated Country are eligible to receive funding for ‘Training and mobility’ actions or when provided for in the specific call/topic conditions. Other international organisations are not eligible to receive funding, unless provided for in the specific call/topic conditions, or if their participation is considered essential for implementing the action by the granting authority.
- Joint Research Centre (JRC)— Where provided for in the specific call conditions, applicants may include in their proposals the possible contribution of the JRC but the JRC will not participate in the preparation and submission of the proposal. Applicants will indicate the contribution that the JRC could bring to the project based on the scope of the topic text. After the evaluation process, the JRC and the consortium selected for funding may come to an agreement on the specific terms of the participation of the JRC. If an agreement is found, the JRC may accede to the grant agreement as beneficiary requesting zero funding or participate as an associated partner, and would accede to the consortium as a member.
- Associations and interest groupings — Entities composed of members (e.g. European research infrastructure consortia (ERICs)) may participate as ‘sole beneficiaries’ or ‘beneficiaries without legal personality’. However, if the action is in practice implemented by the individual members, those members should also participate (either as beneficiaries or as affiliated entities, otherwise their costs will NOT be eligible.
- EU restrictive measures — Entities subject to EU restrictive measures under Article 29 of the Treaty on the European Union (TEU) and Article 215 of the Treaty on the Functioning of the EU (TFEU) as well as Article 75 TFEU, are not eligible to participate in any capacity, including as beneficiaries, affiliated entities, associated partners, third parties giving in-kind contributions, subcontractors or recipients of financial support to third parties (if any).
- Legal entities established in Russia, Belarus, or in non-government controlled territories of Ukraine — Given the illegal invasion of Ukraine by Russia and the involvement of Belarus, there is currently no appropriate context allowing the implementation of the actions foreseen in this programme with legal entities established in Russia, Belarus, or in non-government controlled territories of Ukraine. Therefore, even where such entities are not subject to EU restrictive measures, such legal entities are not eligible to participate in any capacity. This includes participation as beneficiaries, affiliated entities, associated partners, third parties giving in-kind contributions, subcontractors or recipients of financial support to third parties (if any). Exceptions may be granted on a case-by-case basis for justified reasons.
With specific regard to measures addressed to Russia, following the adoption of the Council Regulation (EU) 2024/1745 of 24 June 2024 (amending Council Regulation (EU) No 833/2014 of 31 July 2014) concerning restrictive measures in view of Russia’s actions destabilising the situation in Ukraine, legal entities established outside Russia but whose proprietary rights are directly or indirectly owned for more than 50% by a legal person, entity or body established in Russia are also not eligible to participate in any capacity. - Measures for the protection of the Union budget against breaches of the principles of the rule of law in Hungary — Following the Council Implementing Decision (EU) 2022/2506, as of 16 December 2022, no legal commitments can be entered into with Hungarian public interest trusts established under the Hungarian Act IX of 2021 or any entity they maintain. Affected entities may continue to apply to calls for proposals and can participate without receiving EU funding, as associated partners, if allowed by the call conditions. However, as long as the Council measures are not lifted, such entities are not eligible to participate in any funded role (beneficiaries, affiliated entities, subcontractors, recipients of financial support to third parties, etc.).In case of multi-beneficiary grant calls, applicants will be invited to remove or replace that entity in any funded role and/or to change its status into associated partner. Tasks and budget may be redistributed accordingly.
Additional information
Topics
Relevance for EU Macro-Region
EUSAIR - EU Strategy for the Adriatic and Ionian Region, EUSALP - EU Strategy for the Alpine Space, EUSBSR - EU Strategy for the Baltic Sea Region, EUSDR - EU Strategy for the Danube Region
UN Sustainable Development Goals (UN-SDGs)
Additional Information
Applications must be submitted electronically via the Funders & Tenders Portal electronic submission system (accessible via the topic page in the Search Funding & Tenders section). Paper submissions are NOT possible.
Applications must be submitted using the forms provided inside the electronic submission system (not the templates available on the topic page, which are only for information). The structure and presentation must correspond to the instructions given in the forms.
Applications must be complete and contain all parts and mandatory annexes and supporting documents.
The application form will have two parts:
- Part A (to be filled in directly online) contains administrative information about the applicant organisations (future coordinator and beneficiaries and affiliated entities), the summarised budget for the proposal and call-specific questions;
- Part B (to be downloaded from the Portal submission system, completed and then assembled and re-uploaded as a PDF in the system) contains the technical description of the project.
Annexes and supporting documents will be directly available in the submission system and must be uploaded as PDF files (or other formats allowed by the system).
The limit for a full application (Part B) is 45 pages.
Call documents
Horizon Europe Work Programme 2025 - MissionsHorizon Europe Work Programme 2025 - Missions(1773kB)
Contact
RTD-HORIZON-EUROPE-MISSIONS@ec.europa.eu
Website
National Contact Points for Horizon Europe
Website
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