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  1. An institution, body, office or agency established by or based on the Treaty on European Union and the Treaties establishing the European Communities.

    All education and training facilities for people of different age groups.

    An intergovernmental organization having legal personality under public international law or a specialized agency established by such an international organization. An international organization, the majority of whose members are Member States or Associated Countries and whose main objective is to promote scientific and technological cooperation in Europe, is an International Organization of European Interest.

    An NPO is an institution or organization which, by virtue of its legal form, is not profit-oriented or which is required by law not to distribute profits to its shareholders or individual members. An NGO is a non-governmental, non-profit organization that does not represent business interests. Pursues a common purpose for the benefit of society.

    A partnership, corporation, person, or agency that is for-profit and not operated by the government.

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    A research institution is a legal entity established as a non-profit organization whose main objective is to conduct research or technological development. A college/university is a legal entity recognized by its national education system as a university or college or secondary school. It may be a public or private institution.

    A microenterprise, a small or medium-sized enterprise (business) as defined in EU Recommendation 2003/361. To qualify as an SME for EU funding, an enterprise must meet certain conditions, including (a) fewer than 250 employees and (b) an annual turnover not exceeding EUR 50 million and/or an annual balance sheet total not exceeding EUR 43 million. These ceilings apply only to the figures for individual companies.

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  1. Administration & Governance, Institutional Capacity & Cooperation 

    This topic focuses on strengthening governance, fostering institutional capacity, and enhancing cross-border cooperation. It includes promoting multilevel, transnational, and cross-border governance by designing and testing effective structures and mechanisms, as well as encouraging collaboration between public institutions on various themes. 

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    This topic focuses on preserving, promoting, and enhancing cultural and natural heritage in a sustainable way. It includes efforts to increase the attractiveness of cultural and natural sites through preservation, valorisation, and the development of heritage objects, services, and products. Cultural heritage management, arts, and culture play a key role, including maritime heritage routes, access to cultural sites, and cultural services like festivals, concerts, and art workshops. 

    Tourism development is also central, with actions aimed at promoting natural assets, protecting and developing natural heritage, and increasing touristic appeal through the better use of cultural, natural, and historical heritage. It also covers the improvement of tourist services and products, the creation of ecotourism models, and the development of sustainable tourism strategies. 

    This topic focuses on the sustainable management, protection, and valorisation of natural resources and areas, such as habitats, geo parks, and protected zones. It also includes preserving and enhancing cultural and natural heritage, landscapes, and protecting marine environments. 

    Circular economy initiatives play a key role, with actions aimed at innovative waste management, ecological treatment techniques, and advanced recycling systems. Projects may focus on improving recycling technologies, organic waste recovery, and establishing repair and re-use networks. Additionally, pollution prevention and control efforts address ecological economy practices, marine litter reduction, and sustainable resource use. 

    This topic covers labour market development and employment, focusing on creating job opportunities, optimizing existing jobs, and addressing academic (un)employment and job mobility. It also includes attracting a skilled workforce and improving working conditions for various groups. 

    Strengthening small and medium-sized enterprises (SMEs) and boosting entrepreneurship are key priorities. This includes enhancing SME capacities, supporting social entrepreneurship, and promoting innovative business models. Activities may focus on creating advisory systems for start-ups, spin-offs, and incubators, fostering business networks, and improving the competitiveness of SMEs through knowledge and technology transfer, digital transformation, and sustainable business practices. 

    This topic focuses on fostering community integration and strengthening a common identity by promoting social cohesion, positive relations, and the development of shared spaces and services. It supports initiatives that enhance intercultural understanding and cooperation between different societal groups. 

    Demographic change and migration address key societal challenges, such as an aging population, active aging, and silver economy strategies. It also includes adapting public services and infrastructure to demographic shifts, tackling social and spatial segregation, and addressing brain drain. Migration-related actions cover policy development, strategic planning, and the integration of migrants to create inclusive and resilient communities. 

    All projects where ICT has a significant role, including tailor-made ICT solutions in different fields, as well as digital innovation hubs, open data, Internet of Things; ICT access and connecting (remote) areas with digital infrastructure and services; services and applications for citizens (e-health, e-government, e-learning, e-inclusion, etc.); services and applications for companies (e-commerce, networking, digital transformation, etc.).

    This is about the mitigation and management of risks and disasters, and the anticipation and response capacity towards the actors regarding specific risks and management of natural disasters, for example, prevention of flood and drought hazards, forest fire, strong weather conditions, etc.. It is also about risk assessment and safety.

    This topic focuses on enhancing education, training, and opportunities for children, youth, and adults. It covers the expansion of educational access, reduction of barriers to education, and improvement of higher education and lifelong learning. It also includes vocational education, common learning programs, and initiatives supporting labour mobility and educational networks. Additionally, it addresses the promotion of media literacy, digital learning tools, and the development of innovative educational approaches to strengthen knowledge, skills, and societal participation. 

    This topic emphasizes the role of culture and media in education and social development. It supports initiatives that foster creativity, cultural awareness, and artistic expression among children and youth. Activities include promoting cross-border cooperation in the audiovisual sector, enhancing digital content creation skills, and boosting the distribution of educational and cultural media products. Furthermore, it encourages the development of media literacy initiatives, helping young audiences critically engage with digital and media content. By connecting education, creativity, and media, this topic strengthens cultural identity and supports inclusive, knowledge-based societies. 

    This topic covers actions aimed at improving energy efficiency and promoting the use of renewable energy sources. It includes energy management, energy-saving methods, and evaluating energy efficiency measures. Projects may focus on the energy rehabilitation and efficiency of buildings and public infrastructure, as well as promoting energy efficiency through cooperation among experienced firms, institutions, and local administrations. 

    In the field of renewable energy, this encompasses the development and expansion of wind, solar, biomass, hydroelectric, geothermal, and other sustainable energy sources. Activities include increasing renewable energy production, enhancing research capacities, and developing innovative technologies for energy storage and management. Projects may also address sustainable regional bioenergy policies, financial instruments for renewable energy investments, and the establishment of cooperative frameworks for advancing renewable energy initiatives. 

    This topic focuses on promoting equal rights and strengthening social inclusion, particularly for marginalized and vulnerable groups. It covers activities enhancing the capacity and participation of children, young people, women, elderly people, and socially excluded groups. Activities can address the creation of inclusive infrastructure, improving access and opportunities for people with disabilities, and fostering social cohesion through innovative care services. It also includes initiatives supporting victims of gender-based violence, promoting human rights, and developing policies and tools for social integration and equal participation in society. 

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    This area focuses on the development and improvement of transport and mobility systems, covering all modes of transport, including urban mobility and public transportation. Actions aiming at improving transport connections through traffic and transport planning, rehabilitation and modernisation of infrastructure, better connectivity, and enhanced accessibility. Projects promoting multimodal transport and logistics, optimising intermodal transport chains, offering sustainable and efficient logistics solutions, and developing multimodal mobility strategies. Also, initiatives establishing cooperation among logistic centres and providing access to clean, efficient, and multimodal transport corridors and hubs. 

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Call key data

European Partnership for Brain Health

Funding Program

Horizon Europe: Cluster 1 - Health

Call number

HORIZON-HLTH-2025-02-DISEASE-01

deadlines

Opening
13.05.2025

Deadline
03.06.2025 17:00

Funding rate

30%

Call budget

€ 150,000,000.00

Estimated EU contribution per project

€ 150,000,000.00

Link to the call

ec.europa.eu

Link to the submission

ec.europa.eu

Call content

short description

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”.

Call objectives

The partnership should contribute from the research and innovation angle to priorities set in the “Healthier Together - EU Non-Communicable Diseases Initiative” (2022-2027), which includes a focus area on mental health and neurological disorders, as well as to the “Communication on a comprehensive approach to mental health” (COM(2023) 298 final).

The partnership should also contribute from the research and innovation angle to achieving the objectives of the Pharmaceutical Strategy for Europe, in terms of fulfilling unmet medical needs (numerous in the fields of neurological and mental disorders) and to ensuring that the benefits of innovation reach patients in the EU and Associated Countries. Moreover, it should support the objectives of the EU4Health Programme.

Additionally, the partnership should contribute from the research and innovation angle to the “Communication on the European Care Strategy” (for caregivers and care receivers; COM(2022) 440 final), which aims to ensure high quality, affordable and accessible care services for all ages. By fostering data sharing and boosting FAIR and open data, the partnership should also contribute to the implementation of the European Health Data Space (EHDS).

Thanks to its capacity to bring together different stakeholders (e.g. research funders, health authorities, citizens, healthcare providers, innovators, policymakers), the partnership will create a critical mass of resources to implement a long-term Strategic Research and Innovation Agenda (SRIA), based on the work of the Coordination and Support Action BrainHealth.

The co-funded European Partnership for Brain Health should be implemented based on the priorities identified in the SRIA and through a joint programme of activities ranging from coordinating and funding transnational research to integrative activities aimed at structuring and enhancing the broader research and innovation ecosystem and facilitating the way research and innovation is carried out, and also delivering impact. Examples include (i) facilitating the sharing and analysis of data and samples, (ii) promoting harmonisation and standardisation efforts, (iii) providing input to shape the services provided by research infrastructures (based on the needs of the research community), as well as (iv) networking, training and dissemination activities.

It should be structured along the following main objectives:

  • Strengthening collaboration, strategic alignment and global dialogue: engage and collaborate with key stakeholders, not only those participating in existing EU-supported brain research initiatives but also beyond them, whilst also seeking alignment with these and international initiatives, including other European partnerships.
  • Jointly supporting research and innovation: launch joint transnational calls underpinning the brain health research and innovation priorities, as defined in the SRIA, and based on annual work plans. Calls include research calls, networking calls, and those that relate to ethical, legal and social/societal aspects.
  • Facilitating the use of infrastructures and platforms in the EU and Associated Countries: improve access to and use of these infrastructures and platforms (e.g. ECRIN, EATRIS, EBRAINS, BBMRI, EuroBioImaging, European Genomic Data Infrastructure, etc.), whilst also providing input for shaping the services for the brain health research and funding community. This also covers the facilitation of data sharing by boosting FAIR and open data and improving interoperability and harmonisation.
  • Bridging with healthcare providers, the private sector, regulators, and policymakers: enable the translation of research results into accessible, tailored products, technologies, interventions and policies through collaborations, including with institutionalised European partnerships (e.g., Innovative Health Initiative).
  • Empowering citizens, people living with brain disorders and patients, families and caregivers (including informal): enable them to be active in their health trajectories via the dissemination of good practices and scientific outputs, as well as trainings to engage them along the whole spectrum of the research process.
  • Capacity building in research: support networking and training of scientists, healthcare practitioners, health policy experts, innovators and other professionals contributing to preserve and improve brain health.

The partnership is open to all EU Member States, as well as to countries associated to Horizon Europe and will remain open to third countries wishing to join. Importantly, the EU contribution will not be increased should countries join after signing of the grant agreement.

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Expected effects and impacts

The partnership should include or engage with the following actors: (i) Ministries in charge of R&I policy, as well as national and regional R&I and technology funding agencies and foundations; (ii) Ministries in charge of health and care policy, as well as national and regional healthcare authorities, organisations and providers; (iii) academic researchers; (iv) research infrastructures; (v) patients organisations; (vi) industry; (vii) research and technology organisations; (viii) private sector; and (ix) charities.

The partnership may also encourage engagement with other relevant Ministries (e.g., related to employment, education, etc.) and research funders. It should involve other key actors from civil society and end-users, research and innovation community, innovation owners, health and care systems owners/organisers and health and care agencies.

The partnership should build on and go beyond existing and previous initiatives, including the ERA-NET actions under (i) the EU Joint Programme for Neurodegenerative Disease Research (JPND), (ii) the Network of European Funding for Neuroscience Research (NEURON), and (iii) the Human Brain Project (HBP, a FET Flagship project), as well as the digital research infrastructure EBRAINS, which was put in place by HBP, and the Coordination and Support Actions (CSAs) BrainHealth and European Brain Research Area (EBRA).

The partnership’s governance structure should engage upfront the relevant actors to coordinate, steer and frame the research and innovation activities, and facilitate the use and uptake of the results. The governance should involve key stakeholders, including but not limited to the research and innovation community, patients and citizens, health and care professionals, formal and informal care organisations, and innovation owners. Transparency in governance should be secured (e.g. in calls, governing bodies, etc.).

To ensure coherence and complementarity of activities and leverage knowledge and investment possibilities, the partnership is expected to establish relevant collaborations with other Horizon Europe partnerships (institutionalised and co-funded) and missions, as set out in the working document on ‘Coherence and Synergies of candidate European Partnerships under Horizon Europe’, as well as to explore collaborations with other relevant activities at EU and international level. The proposal should also elaborate on possible synergies with other EU programmes, including EU4Health and the Digital Europe Programme (DIGITAL). The Partnership should align with EU-wide initiatives on open access and FAIR data, including the European Open Science Cloud (EOSC).

To tackle the ambitious challenges, cooperation with international organisations, private sector and non-European institutions and experts may be considered. Participation of third countries is encouraged. Applicants should describe in their proposal the methodology for their collaboration and the aims they want to achieve with this kind of collaboration.

Proposals should pool the necessary financial resources from the participating national research programmes with a view to implementing joint calls for transnational proposals resulting in grants to third parties. Financial support provided by the participants to third parties is one of the activities of this action in order to be able to achieve its objectives.

When defining calls for proposals, this partnership needs to consider the effective contribution of social sciences and humanities (SSH) disciplines and the involvement of SSH experts, institutions as well as the inclusion of relevant SSH expertise, in order to produce meaningful and significant effects enhancing the societal impact of the related research activities. In addition, this partnership needs to integrate robust sex and gender considerations, applying an intersectional lens to investigate variations in mental, neurological and neurodegenerative conditions. This includes examining how characteristics such as sex, gender, age, racial/ethnic background, and disability intersect to influence disease/disorder prevalence, prevention, and outcomes.

Projects funded by the European Partnership for Brain Health will be strongly encouraged to participate in networking and joint activities with relevant projects at European and national levels.

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Expected results

Proposals under this topic should aim to deliver results that are directed, tailored towards and contributing to all the following expected outcomes:

  • The position of the EU and Associated Countries is strengthened as an internationally recognised driver of research and innovation on brain health[1], thereby contributing to the achievement of the Sustainable Development Goals related to neurological and mental health.
  • Research funders align, adopt and implement their brain health research policies allowing for the optimal generation and translation of knowledge into tailored health products and interventions to (i) promote brain health throughout the lifetime, (ii) prevent neurological and mental disorders, and (iii) improve diagnosis, treatment and care to enhance the quality of life of those living with brain disorders, as well as their caregivers, whilst also considering cultural, ethical, legal and social aspects.
  • Research funders, policymakers, relevant agencies and authorities, researchers, innovators, citizens, people living with brain disorders and their caregivers and advocates enhance their collaboration forming a strong, structured and integrated research and innovation ecosystem with shared evidence, tools and methodologies cutting across sectors.
  • The brain health research community at large benefits from and uses an improved comprehensive knowledge framework integrating the EU, national/regional data and information infrastructures to improve transnational research.
  • People living with a brain disorder benefit from (i) a more timely, equitable access to accurate diagnosis and tailored care and treatment options in an innovative, sustainable and high-quality healthcare system that is well integrated with the research community, and from (ii) less discrimination and stigma, and social inclusion.
  • Public and private actors, including civil society (e.g. Non-Governmental Organisations, charities), establish coordinated and efficient multi-stakeholder collaborations at national level in the EU and Associated Countries, allowing for more effective basic and clinical research and enhanced translation into tailored products and interventions.

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Eligibility Criteria

Regions / countries for funding

EU Member States, Overseas Countries and Territories (OCT)
Moldova (Moldova), Albania (Shqipëria), Armenia (Հայաստան), Bosnia and Herzegovina (Bosna i Hercegovina / Босна и Херцеговина), Canada, Faeroes (Føroyar / Færøerne), Georgia (საქართველო), Iceland (Ísland), Israel (ישראל / إِسْرَائِيل), Kosovo (Kosova/Kosovë / Косово), Montenegro (Црна Гора), New Zealand (Aotearoa), North Macedonia (Северна Македонија), Norway (Norge), Serbia (Srbija/Сpбија), Tunisia (تونس /Tūnis), Türkiye, Ukraine (Україна), United Kingdom

eligible entities

EU Body, Education and training institution, Non-Profit Organisation (NPO) / Non-Governmental Organisation (NGO), Other, Private institution, incl. private company (private for profit), Public Body (national, regional and local; incl. EGTCs), Research Institution incl. University, Small and medium-sized enterprise (SME)

Mandatory partnership

Yes

Project Partnership

To be eligible for funding, applicants must be established in one of the following countries:

  • the Member States of the European Union, including their outermost regions
  • the Overseas Countries and Territories (OCTs) linked to the Member States
  • countries associated to Horizon Europe - see list of particpating countries

Only legal entities forming a consortium are eligible to participate in actions provided that the consortium includes, as beneficiaries, three legal entities independent from each other and each established in a different country as follows:

  • at least one independent legal entity established in a Member State; and
  • at least two other independent legal entities, each established in different Member States or Associated Countries.

In recognition of the opening of the US National Institutes of Health’s programmes to European researchers, any legal entity established in the United States of America is eligible to receive Union funding. Because the US contribution will be considered for the calculation of the EU contribution to the partnership, the concerned consortium of research funders from eligible EU Members States and Associated Countries must expressly agree to this participation.

Any legal entity, regardless of its place of establishment, including legal entities from non-associated third countries or international organisations (including international European research organisations) is eligible to participate (whether it is eligible for funding or not), provided that the conditions laid down in the Horizon Europe Regulation have been met, along with any other conditions laid down in the specific call topic.

A ‘legal entity’ means any natural or legal person created and recognised as such under national law, EU law or international law, which has legal personality and which may, acting in its own name, exercise rights and be subject to obligations, or an entity without legal personality.

other eligibility criteria

Specific cases:

  • Affiliated entities (i.e. entities with a legal or capital link to a beneficiary which participate in the action with similar rights and obligations to the beneficiaries, but which do not sign the grant agreement and therefore do not become beneficiaries themselves) are allowed, if they are eligible for participation and funding.
  • Associated partners (i.e. entities which participate in the action without signing the grant agreement, and without the right to charge costs or claim contributions) are allowed, subject to any conditions regarding associated partners set out in the specific call conditions.
  • Entities which do not have legal personality under their national law may exceptionally participate, provided that their representatives have the capacity to undertake legal obligations on their behalf, and offer guarantees to protect the EU’s financial interests equivalent to those offered by legal persons.
  • Legal entities created under EU law (EU bodies) including decentralised agencies may be part of the consortium, unless provided for otherwise in their basic act.
  • International European research organisations are eligible to receive funding. International organisations with headquarters in a Member State or Associated Country are eligible to receive funding for ‘Training and mobility’ actions or when provided for in the specific call/topic conditions. Other international organisations are not eligible to receive funding, unless provided for in the specific call/topic conditions, or if their participation is considered essential for implementing the action by the granting authority.
  • Joint Research Centre (JRC)— Where provided for in the specific call conditions, applicants may include in their proposals the possible contribution of the JRC but the JRC will not participate in the preparation and submission of the proposal. Applicants will indicate the contribution that the JRC could bring to the project based on the scope of the topic text. After the evaluation process, the JRC and the consortium selected for funding may come to an agreement on the specific terms of the participation of the JRC. If an agreement is found, the JRC may accede to the grant agreement as beneficiary requesting zero funding or participate as an associated partner, and would accede to the consortium as a member.
  • Associations and interest groupings — Entities composed of members (e.g. European research infrastructure consortia (ERICs)) may participate as ‘sole beneficiaries’ or ‘beneficiaries without legal personality’. However, if the action is in practice implemented by the individual members, those members should also participate (either as beneficiaries or as affiliated entities, otherwise their costs will NOT be eligible.
  • EU restrictive measures — Entities subject to EU restrictive measures under Article 29 of the Treaty on the European Union (TEU) and Article 215 of the Treaty on the Functioning of the EU (TFEU) as well as Article 75 TFEU, are not eligible to participate in any capacity, including as beneficiaries, affiliated entities, associated partners, third parties giving in-kind contributions, subcontractors or recipients of financial support to third parties (if any).
  • Legal entities established in Russia, Belarus, or in non-government controlled territories of Ukraine — Given the illegal invasion of Ukraine by Russia and the involvement of Belarus, there is currently no appropriate context allowing the implementation of the actions foreseen in this programme with legal entities established in Russia, Belarus, or in non-government controlled territories of Ukraine. Therefore, even where such entities are not subject to EU restrictive measures, such legal entities are not eligible to participate in any capacity. This includes participation as beneficiaries, affiliated entities, associated partners, third parties giving in-kind contributions, subcontractors or recipients of financial support to third parties (if any). Exceptions may be granted on a case-by-case basis for justified reasons.
    With specific regard to measures addressed to Russia, following the adoption of the Council Regulation (EU) 2024/1745 of 24 June 2024 (amending Council Regulation (EU) No 833/2014 of 31 July 2014) concerning restrictive measures in view of Russia’s actions destabilising the situation in Ukraine, legal entities established outside Russia but whose proprietary rights are directly or indirectly owned for more than 50% by a legal person, entity or body established in Russia are also not eligible to participate in any capacity.
  • Measures for the protection of the Union budget against breaches of the principles of the rule of law in Hungary — Following the Council Implementing Decision (EU) 2022/2506, as of 16 December 2022, no legal commitments can be entered into with Hungarian public interest trusts established under the Hungarian Act IX of 2021 or any entity they maintain. Affected entities may continue to apply to calls for proposals and can participate without receiving EU funding, as associated partners, if allowed by the call conditions. However, as long as the Council measures are not lifted, such entities are not eligible to participate in any funded role (beneficiaries, affiliated entities, subcontractors, recipients of financial support to third parties, etc.).In case of multi-beneficiary grant calls, applicants will be invited to remove or replace that entity in any funded role and/or to change its status into associated partner. Tasks and budget may be redistributed accordingly.

Additional information

Topics

Administration & Governance, Institutional Capacity & Cooperation, 
Digitalisation, Digital Society, ICT, 
Health, Social Services, Sports

Relevance for EU Macro-Region

EUSDR - EU Strategy for the Danube Region, EUSBSR - EU Strategy for the Baltic Sea Region, EUSALP - EU Strategy for the Alpine Space, EUSAIR - EU Strategy for the Adriatic and Ionian Region

UN Sustainable Development Goals (UN-SDGs)

project duration

seven to ten years

Additional Information

Applications must be submitted electronically via the Funders & Tenders Portal electronic submission system (accessible via the topic page in the Search Funding & Tenders section). Paper submissions are NOT possible.

Applications must be submitted using the forms provided inside the electronic submission system (not the templates available on the topic page, which are only for information). The structure and presentation must correspond to the instructions given in the forms.

Applications must be complete and contain all parts and mandatory annexes and supporting documents.

The application form will have two parts:

  • Part A (to be filled in directly online) contains administrative information about the applicant organisations (future coordinator and beneficiaries and affiliated entities), the summarised budget for the proposal and call-specific questions;
  • Part B (to be downloaded from the Portal submission system, completed and then assembled and re-uploaded as a PDF in the system) contains the technical description of the project.

Annexes and supporting documents will be directly available in the submission system and must be uploaded as PDF files (or other formats allowed by the system).

The limit for a full application (Part B) is 70 pages.

Beneficiaries may provide financial support to third parties. The support to third parties can only be provided in the form of grants. Financial support provided by the participants to third parties is one of the primary activities of the action in order to be able to achieve its objectives. Given the type of action and its level of ambition, which could entail costly pilot clinical studies, the maximum amount to be granted to each third party is EUR 3.00 million. However, if the objectives of the action would otherwise be impossible or overly difficult (and duly justified in the proposal) the maximum amount may be higher.

The total indicative budget for the topic is EUR 150 million committed in annual instalments over the 3 years, 2025-2027 (EUR 56.5 million from the 2025 budget, EUR 46.5 million from the 2026 budget and EUR 47 million from the 2027 budget).

Call documents

Horizon Europe Work Programme 2025 Cluster 1 - HealthHorizon Europe Work Programme 2025 Cluster 1 - Health(1200kB)

Contact

National Contact Points for Horizon Europe
Website

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