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A European flagship initiative leveraging AI and health data for cardiovascular health and related non-communicable diseases: Advancing Risk Prediction, Prevention, Treatments, Personalised Care and Rehabilitation
Funding Program
EU4Health programme 2021-2027
Call number
EU4H-2026-SANTE-PJ-04
deadlines
Opening
23.09.2025
Deadline
06.01.2026 17:00
Funding rate
60%
Call budget
€ 20,000,000.00
Estimated EU contribution per project
€ 20,000,000.00
Link to the call
Link to the submission
Call content
short description
The initiative is structured around two complementary and mutually reinforcing objectives. Together, they aim to lay the foundations for a European model of AI-enabled cardiovascular and comorbid chronic disease care, grounded in high-quality health data and real-world validated solutions.
Call objectives
This initiative aims to leverage AI and health data to accelerate the early detection, prediction, personalised prevention, integrated management and rehabilitation of CVDs and related NCDs, including rare and complex forms.
Objective 1 — Leveraging Health Data for AI Applications in Cardiovascular and Related Chronic Diseases The first objective is to structure, federate, and enable access to high-quality health data across the Union to support the development, training, validation, and deployment of AI tools focused on cardiovascular diseases and related non-communicable diseases (such as diabetes and obesity). This will align with and prepare for the future application the EHDS, which provides the regulatory and technical framework to enable the secure, privacy preserving, and interoperable secondary use of health data across Member States.
Objective 2 — Deploying AI Solutions for Risk Prediction, Prevention, Treatments, and Personalised Care The second objective is to identify, validate, and scale up mature AI applications capable of improving the risk prediction, early detection, personalised prevention, treatment, and rehabilitation of cardiovascular and related chronic diseases.
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Expected effects and impacts
- Improved health outcomes: Earlier diagnosis and more targeted prevention of NCDs, leading to reduced disease progression, complications, and avoidable mortality.
- Greater equity: Enhanced access to personalised diagnostics and AI-supported care pathways, especially in underserved regions or Member States with limited innovation capacity.
- Efficiency and sustainability of health systems: Better use of resources through predictive and preventive approaches, reducing the burden of chronic conditions on healthcare infrastructures.
- Trust in European health AI: By ensuring compliance with data protection, safety, and transparency standards, the initiative will foster trust in the responsible use of AI for health in line with the AI Act and EHDS Regulation. It will also support the uptake — and where relevant, the development — of specifications and standards foreseen under both frameworks, notably for interoperability, risk management and data governance
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Expected results
This initiative is expected to generate tangible, scalable results supporting the adoption of AIdriven personalised care for cardiovascular diseases and related non-communicable conditions, while laying the foundations of a trusted European data ecosystem for health innovation.
Expected results – Data dimension
- Creation of a large-scale, federated, high-quality dataset for cardiovascular and metabolic diseases, aligned with the EHDS framework. This dataset will be representative, inclusive, and interoperable, and will enable the development, training and benchmarking of AI tools across borders.
- Definition and uptake of minimum technical specifications for cardiovascular datasets, including structured phenotypes, genetic and biometric markers, and metadata quality labelling.
Expected results – AI adoption dimension
- Validated AI solutions: A portfolio of AI tools will be piloted in real-world clinical settings, with demonstrated effectiveness in early detection, risk prediction, and personalised prevention of cardiovascular and related chronic diseases.
- Deployment frameworks: The initiative will produce practical guidelines and protocols to facilitate the integration and scale-up of AI applications across diverse healthcare systems. These will cover governance, interoperability, clinician training, patient engagement, and continuous performance monitoring.
- Strategic guidance: The publication of a roadmap and a blueprint for large-scale integration will inform health authorities, hospitals, and policymakers on how to responsibly and sustainably adopt AI tools, supporting informed decisions at national and Union levels.
- Robust evidence base: The project will generate comparative data on safety, performance (e.g. sensitivity, specificity, cost-effectiveness), usability and acceptability, informing both clinical practice and health policy.
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Eligibility Criteria
Regions / countries for funding
Moldova (Moldova), Bosnia and Herzegovina (Bosna i Hercegovina / Босна и Херцеговина), Iceland (Ísland), Montenegro (Црна Гора), Norway (Norge), Ukraine (Україна)
eligible entities
Education and training institution, International organization, Non-Profit Organisation (NPO) / Non-Governmental Organisation (NGO), Other, Private institution, incl. private company (private for profit), Public Body (national, regional and local; incl. EGTCs), Research Institution incl. University, Small and medium-sized enterprise (SME)
Mandatory partnership
Yes
Project Partnership
In order to be eligible, the applicants (beneficiaries and affiliated entities) must:
- be legal entities (public or private bodies)
- be established in one of the eligible countries, i.e.:
- EU Member States (including overseas countries and territories (OCTs))
- listed EEA countries and countries associated to the EU4Health Programme (list of participating countries)
Proposals must be submitted by a consortium of at least 5 beneficiaries from 5 different eligible countries.
other eligibility criteria
Specific cases
- Natural persons are NOT eligible (with the exception of self-employed persons, i.e. sole traders, where the company does not have legal personality separate from that of the natural person).
- International organisations are eligible. The rules on eligible countries do not apply to them.
- Entities which do not have legal personality under their national law may exceptionally participate, provided that their representatives have the capacity to undertake legal obligations on their behalf, and offer guarantees for the protection of the EU financial interests equivalent to that offered by legal persons
- EU bodies (with the exception of the European Commission Joint Research Centre) can NOT be part of the consortium.
- Associations and interest groupings - entities composed of members may participate as ‘sole beneficiaries’ or ‘beneficiaries without legal personality’. Please note that if the action will be implemented by the members, they should also participate (either as beneficiaries or as affiliated entities, otherwise their costs will NOT be eligible).
- European Reference Networks (ERNs) — These cover networks between healthcare providers and centres of expertise in the Member States to reinforce healthcare cooperation, in particular in the area of rare diseases, in line with the objectives set out in Article 12 of Directive 2011/24.
- Countries currently negotiating association agreements — Beneficiaries from countries with ongoing negotiations for participation in the programme (see list of participating countries) may participate in the call and can sign grants if the negotiations are concluded before grant signature and if the association covers the call (i.e. is retroactive and covers both the part of the programme and the year when the call was launched).
- EU restrictive measures — Special rules apply for entities subject to EU restrictive measures under Article 29 of the Treaty on the European Union (TEU) and Article 215 of the Treaty on the Functioning of the EU (TFEU). Such entities are not eligible to participate in any capacity, including as beneficiaries, affiliated entities, associated partners, subcontractors or recipients of financial support to third parties (if any).
- EU conditionality measures — Special rules apply for entities subject to measures adopted on the basis of EU Regulation 2020/209214. Such entities are not eligible to participate in any funded role (beneficiaries, affiliated entities, subcontractors, recipients of financial support to third parties, etc). Currently such measures are in place for Hungarian public interest trusts established under the Hungarian Act IX of 2021 or any entity they maintain (see Council Implementing Decision (EU) 2022/2506, as of 16 December 2022).
Additional information
Topics
Relevance for EU Macro-Region
EUSAIR - EU Strategy for the Adriatic and Ionian Region, EUSALP - EU Strategy for the Alpine Space, EUSBSR - EU Strategy for the Baltic Sea Region, EUSDR - EU Strategy for the Danube Region
UN Sustainable Development Goals (UN-SDGs)
project duration
between 24 and 36 months
Additional Information
Proposals must be submitted electronically via the Funding & Tenders Portal Electronic Submission System. Paper submissions are NOT possible.
Proposals must be complete and contain all the requested information and all required annexes and supporting documents:
- Application Form Part A — contains administrative information about the participants (future coordinator, beneficiaries and affiliated entities) and the summarised budget for the project (to be filled in directly online)
- Application Form Part B — contains the technical description of the project (template to be downloaded from the Portal Submission System, completed, assembled and re-uploaded)
- mandatory annexes and supporting documents (templates to be downloaded from the Portal Submission System, completed, assembled and re-uploaded):
- detailed budget table/calculator
- CVs (standard) of core project team
- list of previous projects (key projects for the last 4 years) (template available in Part B)
Proposals are limited to maximum 70 pages (Part B).
Financial support to third parties is allowed for grants or similar forms of support under the following conditions:
- the calls must be open, published widely and conform to EU standards concerning transparency, equal treatment, conflict of interest and confidentiality
- the calls must remain open for at least two months
- the outcome of the call must be published on the participants’ websites, including a description of the selected projects, award dates, project durations, and final recipient legal names and countries
- the calls must have a clear European dimension.
Call documents
Call Document EU4H-2026-SANTE-PJCall Document EU4H-2026-SANTE-PJ(1036kB)
Contact
Website
HaDEA- EU4 Health
HaDEA-HP-CALLS@ec.europa.eu
Website
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