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  1. An institution, body, office or agency established by or based on the Treaty on European Union and the Treaties establishing the European Communities.

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  1. Administration & Governance, Institutional Capacity & Cooperation 

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Call key data

Agri-food Biotech Scaling-up

Funding Program

Single Market Programme

Call number

SMP-COSME-2026-BIOAGRIFOOD

deadlines

Opening
25.03.2026

Deadline
02.06.2026 17:00

Funding rate

90%

Call budget

€ 3,000,000.00

Estimated EU contribution per project

€ 1,500,000.00

Link to the call

Link to the submission

Call content

short description

This call for proposals aims to support projects, bringing together biotech clusters from different countries participating in the Single Market Programme (SMP). Each selected project will create a partnership aiming at gathering clusters, SMEs and other relevant stakeholders to reach a critical mass and develop structured collaboration enabling to compete with global hubs. Projects will have to contribute to EU priorities such as strategic autonomy, sustainability, resilience and food security.

Call objectives

The projects will provide scale-up support tailored to SMEs’ needs – from applied R&D and co-innovation to piloting and demonstration – to strengthen their pathway towards first commercial production. They will also offer regulatory support to help SMEs navigate the relevant regulatory pathways for bringing their products to market.

Each SME will receive at least one type of support – either scale-up support to advance the product or process to the next development phase, or regulatory support to prepare for and achieve market entry. Where both are relevant to the SME’s needs and can be delivered within available resources, combined support can be offered.

Projects are expected to focus on advanced fermentation for food and feed applications in the agri-food sector. Advanced fermentation refers to fermentation processes beyond traditional applications, including biomass and precision fermentation, that use specialised microorganisms to produce targeted outputs.

Proposals must cover all of the following priorities:

  • establish a coherent strategic direction;
  • facilitate knowledge exchange and networking;
  • provide relevant scale-up support, including the use of appropriately equipped facilities;
  • offer targeted advice in preparing regulatory dossiers.

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Expected effects and impacts

The impact of the mandatory activities must be assessed against the following mandatory Key Performance Indicators (KPIs):

  • Number of collaboration activities (such as workshops, webinars, and other knowledge-exchange or networking events), with a minimum of 3 activities 
  • Number of participants in all collaboration activities in total, with a minimum of 60 participants
  • Number of SMEs receiving entry-level support (through sub-activity 2.4), with a minimum of 30 SMEs
  • Number of SMEs receiving scale-up support (through sub-activity 3.1), with a minimum of 3 SMEs
  • Number of SMEs receiving regulatory support (through sub-activity 3.2), with a minimum of 3 SMEs
  • Number of SMEs receiving support under activity 3 overall, with a minimum of 10 SMEs

Furthermore, proposals must measure the following overarching indicators from the Single Market Programme:

  1. Number of SMEs, clusters and business network organisations, as well as business support organisations, receiving support from the programme, in particular for internationalisation, digitalisation and sustainability.
  2. Number of companies supported having concluded business partnerships.
  3. Number of entrepreneurs benefitting from mentoring and mobility schemes, including young, new and female entrepreneurs, as well as other specific target groups.

Applicants must include the above indicators and also propose further SMART (i.e. Specific, Measurable, Attainable, Relevant and Timely) indicators. The proposal must include target values and measurable quality standards for the proposed indicators. The set of proposed indicators, including the above listed mandatory KPIs, must be included in the Application Form (Section 3.1. Impact and Ambition).

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Expected results

The project will include, at least the following mandatory activities:

Mandatory activity 1: Develop a strategy

The project must develop a comprehensive strategy for the partnership, which must define a clear vision and mission focused on structured collaboration to reach world-class scale and boost the competitiveness of the companies in the partnership.

The structured collaboration should include the systematic analysis of synergies between the companies in the partnership and the identification of potential synergies with the other project funded under this call for proposals to enhance collective impact.

The emphasis of the strategy must be on advanced fermentation for food and feed applications, but broader bio-based approaches that contribute to the bioeconomy may be incorporated where relevant.

The strategy must include at least the elements set out below.

  • A marketing identity for the partnership, including a distinctive name.
  • An explanation of how the partnership will support advanced fermentation as applied in food and feed production.
  • An overview of potential synergies and coordination opportunities with the other project funded under this call.
  • A timed roadmap on the development of structured collaboration, focused on innovation, start-up and scale-up support. This must also outline how the partnership will aim to operate beyond the project period, for example by exploring strategies for maintaining partner collaboration, potential revenue models or funding mechanisms for SME support.
  • A market analysis assessing the competitive environment, the partnership’s strategic positioning, and market opportunities and challenges for its SMEs in both European and international markets. For the international markets, the most promising non-EU markets must be chosen and a global commercialisation and representation approach for the SMEs must be defined. It is expected that, where appropriate, the SMEs of the partnership will be represented on those markets by the clusters (or similar organisations) leading the partnership. At least two international markets must be identified and the rationale behind this choice must be explained.
  • A needs analysis identifying the conditions and capabilities required to develop, maintain, or relocate advanced fermentation production to Europe. The analysis should assess the structural enablers for competitive industrial-scale production in Europe, including infrastructure, cost competitiveness, the regulatory environment, skills availability, and access to finance. The primary focus should be on the specific needs of companies in the partnership to develop, maintain, or relocate production to the EU – particularly where their innovation capacity (including technologies and patents) and production capabilities are relevant to EU food security objectives. Based on this assessment, the strategy should set out concrete proposals, including on investments, to enable EU-based production.

The consortium applying for this call for proposals must have the operational means to coordinate the development of this strategy and establish the operational framework for the partnership. The strategy must specify how the partnership will leverage the expertise and infrastructure of its consortium partners, as well as contributions from external collaborators who are not funded by the project (e.g. related initiatives, networks or projects).

Mandatory activity 2: Foster network collaboration and identify SMEs for support

Sub-activity 2.1: Build a network of partners
Sub-activity 2.2: Identify and select SMEs
Sub-activity 2.3: Organise collaboration activities
Sub-activity 2.4.: Engage SMEs through entry-level support

Mandatory activity 3: Support SMEs by delivering scale-up support and/or providing regulatory support

The project must support a minimum of 10 SMEs receiving one-on-one assistance tailored to their specific needs. This support must cover at least three SMEs under sub-activity 3.1 and at least three SMEs under sub-activity 3.2. The project must maximise the value and impact of its support by committing fully to each SME with sufficient resources, time and expertise.

The support must include process development services and regulatory guidance and, where appropriate and subject to SME readiness and the availability of project resources, access to facilities for scale-up validation. This in-depth support is expected to require significant time and resources per SME, for example through sustained process optimisation and scale-up activities, or through ongoing regulatory support involving the preparation and review of data and documentation over an extended period. Accordingly, the number of SMEs that can be supported under these activities will be limited.

The proposal must explain in detail the support services to be developed, the methodology for delivering each type of support, and the roles of consortium partners (including any affiliated entities) and other service providers, including subcontractors, involved in delivery. All support is expected to be delivered directly to selected SMEs as in-kind support.

Mandatory activity 4: Communicate about the project and disseminate its outputs

The project must implement a comprehensive communication and dissemination strategy to create visibility, reach SMEs, and share learnings with the broader agri-food biotech ecosystem.

The project must develop and disseminate relevant materials, such as:

  • success stories of SMEs that successfully scaled through project support;
  • technical guides or toolkits on process scale-up or regulatory pathways;
  • lessons learnt, such as sustainability considerations and policy recommendations.

The project must promote such materials and its activities through the European Cluster Collaboration Platform (ECCP). This must include regular updates on project activities and achievements, and active engagement with other clusters and initiatives on the platform. Promotion should also be carried out through other appropriate communication channels, including professional networks and social media (e.g. LinkedIn) to maximise visibility and outreach.

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Eligibility Criteria

Regions / countries for funding

Candidate Countries, EU Member States, Overseas Countries and Territories (OCT)
Armenia (Հայաստան), Georgia (საქართველო), Iceland (Ísland), Liechtenstein, Norway (Norge)

eligible entities

Education and training institution, International organization, Non-Profit Organisation (NPO) / Non-Governmental Organisation (NGO), Other, Private institution, incl. private company (private for profit), Public Body (national, regional and local; incl. EGTCs), Research Institution incl. University, Small and medium-sized enterprise (SME)

Mandatory partnership

Yes

Project Partnership

In order to be eligible, the applicants (beneficiaries, affiliated entities and associated partners) must:

  • be legal entities (public or private bodies);
  • be established and registered in one of the eligible countries, i.e.:
    • EU Member States
    • non-EU countries (not for coordinator and single applicant):

Proposals must be submitted by a consortium of at least three applicants (beneficiaries; not affiliated entities) from at least two different eligible countries, which complies with the following conditions:

  • at least two cluster organisations (see definition below) or cluster networks from two different EU Member States that:
    • are registered or have a pending registration request to the ECCP by the submission deadline of this call for proposals;
    • have a proven track record of at least three years in supporting biotech SMEs in the food and/or feed sector.
  • any other relevant organisation(s) suitable for the implementation of the project.

For the purpose of this call for proposals, cluster organisations are understood as the legal entities that support the strengthening of collaboration, networking and learning in innovation clusters and act as innovation support providers by providing or channelling specialised and customised business support services to stimulate innovation activities, especially in SMEs. They are usually the actors that facilitate strategic partnering across clusters.

It is requested that all applicants (beneficiaries and affiliated entities) fill in Annex 5 to Part B - Eligibility checklist by providing:

  • For cluster organisations and cluster networks from an EU Member State: a short description of their activities justifying a track record of at least 3 years in supporting biotech SMEs in the food and/or feed sectors;
  • For cluster organisations and cluster networks from an EU Member State already registered in the European Cluster Collaboration Platform: the link to the completed cluster organisation profile for each applicant registered on the Platform must be provided; or
  • For cluster organisations and cluster networks from an EU Member State not yet registered on the European Cluster Collaboration Platform: for each applicant, a declaration on their honour that they represent a cluster organisation or a business network organisation offering or channelling innovative support services to businesses (in compliance with the definition of ‘innovation clusters’), together with proof that a cluster profile has been submitted to the ECCP for registration and is pending, with the respective information included in the descriptive form.

! Non concurrent participation!

It is recalled that individual applicants (beneficiaries and affiliated entities) cannot participate in several proposals under this call for proposals. If such a case is detected by the funding body, it will lead to the rejection of the applicant concerned. The respective consortia affected by the rejection of an applicant must still fulfil all the eligibility criteria stipulated in this section 6.

other eligibility criteria

Specific cases

Exceptional funding — Entities from other countries (not listed above) are exceptionally eligible, if the granting authority considers their participation essential for the implementation of the action.

Natural persons — Natural persons are NOT eligible (with the exception of self-employed persons, i.e. sole traders, where the company does not have legal personality separate from that of the natural person).

International organisations — International organisations are eligible. The rules on eligible countries do not apply to them.

Entities without legal personality (including social partner organisations) — Entities which do not have legal personality under their national law may exceptionally participate, provided that their representatives have the capacity to undertake legal obligations on their behalf, and offer guarantees for the protection of the EU financial interests equivalent to that offered by legal persons.

EU bodies — EU bodies (with the exception of the European Commission Joint Research Centre) can NOT be part of the consortium.

Associations and interest groupings — Entities composed of members may participate as ‘sole beneficiaries’ or ‘beneficiaries without legal personality’.

Countries currently negotiating association agreements — Beneficiaries from countries with ongoing negotiations for participation in the programme (see list of participating countries above) may participate in the call and can sign grants if the negotiations are concluded before grant signature and if the association covers the call (i.e. is retroactive and covers both the part of the programme and the year when the call was launched).

EU restrictive measures — Special rules apply for entities subject to EU restrictive measures under Article 29 of the Treaty on the European Union (TEU) and Article 215 of the Treaty on the Functioning of the EU (TFEU). Such entities are not eligible to participate in any capacity, including as beneficiaries, affiliated entities, associated partners, subcontractors or recipients of financial support to third parties (if any).

EU conditionality measures — Special rules apply for entities subject to measures adopted on the basis of EU Regulation 2020/20928. Such entities are not eligible to participate in any funded role (beneficiaries, affiliated entities, subcontractors, recipients of financial support to third parties, etc). Currently such measures are in  place for Hungarian public interest trusts established under the Hungarian Act IX of 2021 or any entity they maintain (see Council Implementing Decision (EU) 2022/2506, as of 16 December 2022).

Additional information

Topics

Agriculture & Forestry, Fishery, Food, Soil quality, 
Competitiveness of Enterprises, Employment/Labour Market, SME & entrepreneurship

Relevance for EU Macro-Region

EUSAIR - EU Strategy for the Adriatic and Ionian Region, EUSALP - EU Strategy for the Alpine Space, EUSBSR - EU Strategy for the Baltic Sea Region, EUSDR - EU Strategy for the Danube Region

UN Sustainable Development Goals (UN-SDGs)

project duration

36 months

Additional Information

Proposals must be submitted electronically via the Funding & Tenders Portal Electronic Submission System (accessible via the Topic page in the Search Funding & Tenders section. Paper submissions are NOT possible.

Proposals (including annexes and supporting documents) must be submitted using the forms provided inside the Submission System (NOT the documents available on the Topic page — they are only for information). No modification to the format of these documents is allowed.

Proposals must be complete and contain all the requested information and all required annexes and supporting documents:

  • Application Form Part A — contains administrative information about the participants (future coordinator, beneficiaries, affiliated entities and associated partners) and the summarised budget for the project (to be filled in directly online)
  • Application Form Part B — contains the technical description of the project (to be downloaded from the Portal Submission System, completed and then assembled and re-uploaded as PDF in the system)
  • mandatory annexes and supporting documents (to be uploaded as a separate PDF files):
    • detailed budget table/calculator (template available in the Submission System; Tpl_Detailed Budget Table (SMP COSME GFS 90)).
    • list of previous projects (key projects for the last 4 years) (template available in Part B).
    • Annex 5 to Part B - Eligibility checklist (that can be downloaded from EISMEA’s call page and will need to be uploaded dully filled and signed together (as a single document) with the technical annex of the proposal entitled ‘Application Form Part B’ (SMP COSME) document. Please check carefully also Section 6 ‘Eligibility’ of this call for proposals).

Proposals are limited to maximum 50 pages.


Financial support to third parties is not allowed.